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KMID : 1123920030170020499
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 2 p.499 ~ p.502
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Effect of Aconiti Radix on Cultured Cerebral Neurons Damaged by Reactive Oxygen Species
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Shim Jae-Han
Lee Eun-Mi
Lee Joung-Hwa
Kim Dae-Geun
Lee Young-Chan
Kang Jeong-Ho
Park Sin-Kee
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Abstract
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Neurotoxicity of reactive oxygen species(ROS) and neuroprotective effect of Aconiti Radix(AR) against ROS-induced cytotoxicity were determined on cultured mouse cerebral neurons by MTT assay after cerebral neurons were cultured for 5 hours in various concentrations of GO. GO was toxic in a dose-dependent manner on cultured cerebral neurons after cerebral neurons were incubated for 5 hours in media containing 5～40mU/ml GO. While, cultures were pretreated with 180 μg/ml AR for 2 hours increased remarkably cell viability. From these results, it is suggested that GO has toxic effect on cultured mouse cerebral neurons by the decrease of cell viability. And also, herb extract such as AKR is very effective in the protection pf neurotoxicity induced by GO.
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KEYWORD
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Glucose oxidase, Cultured cerebral neuron, Aconiti Radix
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